解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Base excision repair (BER) and nucleotide excision repair (NER) pathways repair damaged DNA, and polymorphisms in these genes might affect breast cancer susceptibility. We evaluated associations between seven single-nucleotide polymorphisms in four DNA repair genes (ERCC4 rs1799801, XPC rs2227998, rs2228001, rs2228000...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgr096
更新日期:2011-08-01 00:00:00
abstract::Genetic risk factors for sporadic neuroendocrine tumors (NET) are poorly understood. We tested risk associations in patients with sporadic NET and non-cancer controls, using a custom array containing 1536 single-nucleotide polymorphisms (SNPs) in 355 candidate genes. We identified 18 SNPs associated with NET risk at a...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgr095
更新日期:2011-08-01 00:00:00
abstract::Estrogens are major risk factors for the development of breast cancer; they can be metabolized to catechols, which are further oxidized to DNA-reactive quinones and semiquinones (SQs). These metabolites are mutagenic and may contribute to the carcinogenic activity of estrogens. Redox cycling of the SQs and subsequent ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgr109
更新日期:2011-08-01 00:00:00
abstract::Overexpressed DNA methyltransferase 1 (DNMT1) strongly contributes to tumor suppressor gene silencing in colorectal cancer (CRC). However, the underlying mechanism of DNMT1 overexpression is still unclear. MicroRNAs (miRNA) have been implicated as gene regulators controlling diverse biological processes, including car...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgr081
更新日期:2011-07-01 00:00:00
abstract::Recent studies have implicated multipotential mesenchymal stem cells (MSCs) as an aid to breast cancer cell proliferation and metastasis, partly as a result of the MSCs secretome. As the tumor gets beyond 2 mm in diameter, the stromal cells could undergo starvation due to the lack of sufficient nutrients in solid tumo...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgr029
更新日期:2011-07-01 00:00:00
abstract::The magnitude of benefit is variable for advanced non-small cell lung cancer (NSCLC) patients receiving platinum-based chemotherapy. The purpose of this study is to determine whether genetic variations in the transforming growth factor-beta (TGF-β) pathway are associated with clinical outcomes in NSCLC patients receiv...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgr067
更新日期:2011-07-01 00:00:00
abstract::Cyclin E is reported to be an important cell cycle regulator, and its dysregulation is implicated in tumorigenesis including esophageal squamous cell carcinoma (ESCC). MicroRNAs (miRNAs) regulate gene expression at the posttranscriptional level and play important roles in tumor initiation and progression. However, the...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgr078
更新日期:2011-07-01 00:00:00
abstract::Hepatocellular carcinoma (HCC), one of the most prevalent and lethal cancers, has shown an alarming rise in the USA. Without effective therapy for HCC, novel chemopreventive strategies may effectively circumvent the current morbidity and mortality. Oxidative stress predisposes to hepatocarcinogenesis and is the major ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgr045
更新日期:2011-06-01 00:00:00
abstract::Glucuronide conjugates of 4-aminobiphenyl and its N-hydroxy metabolite can be rapidly hydrolyzed in acidic urine to undergo further metabolic activation and form DNA adducts in the urothelium. We conducted a large multicenter case-control study in Spain to explore the etiology of bladder cancer and evaluated the assoc...
journal_title:Carcinogenesis
pub_type: 杂志文章,多中心研究
doi:10.1093/carcin/bgr048
更新日期:2011-06-01 00:00:00
abstract::p90 Ribosomal S6 kinase (RSK) 4 is a serine-threonine kinase that belongs to the p90RSK family. RSK4 has been proposed as a tumor suppressor gene, related with anti-invasive activity, inhibition of the RAS-mitogen-activated protein kinase (MAPK) pathway and induction of senescence. Despite the related findings, little...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgr003
更新日期:2011-04-01 00:00:00
abstract::Low vitamin E and selenium (Ve/Se) nutritional status is known to be associated with increased risk of esophageal squamous cell carcinoma (ESCC). A previous human intervention trial demonstrated that Ve/Se supplementation decreased the occurrence of esophageal cancer death among younger participants but not among olde...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq279
更新日期:2011-03-01 00:00:00
abstract::Patients with inflammatory bowel diseases are at increased risk for colorectal cancer. Pharmacological inhibition of cyclooxygenase (COX) function exacerbates symptoms in colitis patients. Animal models of colitis using Cox-2-knockout mice and COX inhibitors also indicate that COX-2 has a protective role against colon...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq268
更新日期:2011-03-01 00:00:00
abstract::Yes-associated protein (YAP), the nuclear effector of the Hippo pathway, is a key regulator of organ size and a candidate human oncogene located at chromosome 11q22. Since we previously reported amplification of 11q22 region in esophageal squamous cell carcinoma (ESCC), in this study we focused on the clinical signifi...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq254
更新日期:2011-03-01 00:00:00
abstract::We have studied the influence of genetic polymorphisms in the xenobiotic-metabolizing genes GSTM1, GSTP1, GSTT1, EPHX1, NAT1 and NAT2 and the folate-metabolizing genes MTR and MTHFR on the frequencies of cells with chromosomal aberrations (CAs) in peripheral lymphocytes of Norwegian men. Log-linear Poisson regression ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq246
更新日期:2011-03-01 00:00:00
abstract::Lung cancer continues to be the leading cause of cancer death in the USA and the best example of a cancer with undisputed evidence of environmental risk. However, a genetic contribution to lung cancer has also been demonstrated by studies of familial aggregation, family-based linkage, candidate gene studies and most r...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq252
更新日期:2011-03-01 00:00:00
abstract::A hallmark of cancer is aberrant DNA methylation, consisting of global hypomethylation and regional hypermethylation of tumor suppressor genes. DNA methyltransferase inhibitors have been recognized as promising candidate anticancer drugs. Drug development has focused on DNA methylation inhibitors with the goal of acti...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq221
更新日期:2011-02-01 00:00:00
abstract::2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), the most abundant heterocyclic amine produced during the cooking of meats and fish, is suspected to be a human carcinogen. Metabolic activation of PhIP is primarily mediated by the enzyme cytochrome P450 (CYP) 1A2. Metabolism of PhIP by CYP1A2 differs considerabl...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq235
更新日期:2011-02-01 00:00:00
abstract::Resveratrol is a naturally occurring trihydroxyl-diphenylethylene compound that has been shown experimentally to have beneficial effects in the treatment of cancer and cardiovascular disease. Resveratrol induces programmed cell death (apoptosis) in these cells and activates important signal transducing proteins includ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq212
更新日期:2011-01-01 00:00:00
abstract::Oxidative DNA modifications such as 7,8-dihydro-8-oxoguanine (8-oxoG) are generated endogenously in apparently all living cells. The defect of the repair of 8-oxoG in Csb(m/m)Ogg1⁻(/)⁻ mice results in elevated basal levels of these lesions and increased frequencies of spontaneous mutations, which initiate tumorigenesi...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq196
更新日期:2011-01-01 00:00:00
abstract::Epigenetic silencing of tumor suppressor genes commonly occurs in human cancers via increasing DNA methylation and repressive histone modifications at gene promoters. However, little is known about how pathogenic environmental factors contribute to cancer development by affecting epigenetic regulatory mechanisms. Prev...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq197
更新日期:2010-12-01 00:00:00
abstract::Pharmacological inhibitors of the transforming growth factor β (TGFβ) type I receptor (ALK5) have shown promise in blocking growth of xenotransplanted cancer cell lines but the effect on a multistage cancer model is not known. To test this, we treated mouse skin with SB431542 (SB), a well-characterized ALK5 inhibitor,...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq191
更新日期:2010-12-01 00:00:00
abstract::Measurement of carcinogen DNA adducts in blood has been used as a surrogate for the target lung tissue. We aimed to examine whether genetic polymorphisms in several metabolic pathway genes modify the relation between DNA adducts in target lung and blood. One hundred and thirty-five early-stage lung cancer patients fro...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq208
更新日期:2010-12-01 00:00:00
abstract::Tuberin (protein encodes by tuberous sclerosis complex 2, Tsc2) deficiency is associated with the decrease in the DNA repair enzyme 8-oxoG-DNA glycosylase (OGG1) in tumour kidney of tuberous sclerosis complex (TSC) patients. The purpose of this study was to elucidate the mechanisms by which tuberin regulates OGG1. The...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq189
更新日期:2010-11-01 00:00:00
abstract::Genome-wide DNA hypomethylation was one of the first epigenetic alterations described in cancer cells. However, the cause of this hypomethylation is still poorly understood. We have previously developed a line of primary mesenchymal stem cells (MSC, the putative origin of various types of sarcoma) in which five oncoge...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq080
更新日期:2010-10-01 00:00:00
abstract::The human DNA polymerase lambda (Polλ) is a DNA repair polymerase, which is believed not only to play a role in base excision repair but also to contribute to DNA double-strand break repair by non-homologous end joining. We described here that cellular expression of the recently described natural polymorphic variant o...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq166
更新日期:2010-10-01 00:00:00
abstract::The role of tumor estrogen receptors (ERs) and serum estrogen in lung cancer is inconclusive. We investigated the hypothesis that ERs and functional single-nucleotide polymorphisms in the estrogen biosynthesis pathway are associated with poorer lung cancer survival. Lung cancer patients (n = 305) from a National Cance...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq156
更新日期:2010-10-01 00:00:00
abstract::Nitric oxide (NO) has been shown to induce double strand DNA breaks in Barrett's oesophagus (BO) and in other cancers has a role in invasion. The specific aims of this study were to investigate whether NO can induce invasion in cells representative of different stages of Barrett's progression and to determine possible...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq130
更新日期:2010-09-01 00:00:00
abstract::Conjugated linoleic acid (CLA) is a class of commercially available fatty acids that have been associated with anticancer properties in rodent models of chemical carcinogenesis. We conducted a pilot study to examine the antitumor effect of dietary CLA in a polyoma virus-middle T antigen (PyMT) mouse model of invasive ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq148
更新日期:2010-09-01 00:00:00
abstract::Docosahexaenoic acid (DHA), a 22:6 n-3 polyunsaturated fatty acid, is the longest and most highly unsaturated fatty acid found in most membranes and has been shown to inhibit cancer cell growth in part by modifying cell signaling. In the current study, alterations to epidermal growth factor receptor (EGFR) signaling u...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq111
更新日期:2010-09-01 00:00:00
abstract::Insulin-like growth factor-binding protein (IGFBP)-3 is overexpressed frequently in esophageal squamous cell carcinoma. Yet, the role of IGFBP3 in esophageal tumor biology remains to be elucidated. We find that IGFBP3 facilitates transforming growth factor (TGF)-beta1-mediated epithelial-to-mesenchymal transition (EMT...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq108
更新日期:2010-08-01 00:00:00
abstract::An ongoing controversy exists on beneficial versus harmful effects of high beta-carotene (BC) intake, especially for the lung. To elucidate potential mechanisms, we studied effects of BC on lung gene expression. We used a beta-carotene 15,15'-monooxygenase 1 (Bcmo1) knockout mouse (Bcmo1(-/-)) model, unable to convert...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq083
更新日期:2010-08-01 00:00:00
abstract::Checkpoint kinase (CHEK) 2, a tumor suppressor gene, plays an essential role in the DNA damage checkpoint response cascade. We first investigated two polymorphisms in the proximal promoter of the CHEK2 gene and evaluated their associations with the risk of lung cancer in a case-control study using 500 incident lung ca...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq089
更新日期:2010-07-01 00:00:00
abstract::The incidence of esophageal adenocarcinoma (EA) has been increasing rapidly, particularly among white males, over the past few decades in the USA. However, the etiology of EA and the striking male predominance is not fully explained by known risk factors. To identify susceptible genes for EA risk, we conducted a pathw...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq092
更新日期:2010-07-01 00:00:00
abstract::Despite their individual key roles in promoting head and neck squamous cell carcinoma (HNSCC) progression and treatment resistance, little is known about the impact of intratumoral hypoxia on the activity of the epidermal growth factor receptor (EGFR) signaling pathway in this cancer type. Here, we show that in highly...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq078
更新日期:2010-07-01 00:00:00
abstract::Low selenium (Se) status correlates with increased risk of colorectal cancer (CRC). Since Se exerts its biological roles through the selenoproteins, genetic variations in selenoprotein genes may influence susceptibility to CRC. This study analysed 12 single-nucleotide polymorphisms (SNPs) in selenoprotein genes [gluta...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq076
更新日期:2010-06-01 00:00:00
abstract::Childhood cancer is the leading cause of disease-related death in children aged 1-14 years in Canada and the USA and it has been hypothesized that transplacental exposure to environmental carcinogens such as benzene may contribute to the etiology of these cancers. Our objectives were to determine if transplacental ben...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq074
更新日期:2010-06-01 00:00:00
abstract::In light of clinical and biological evidence that bile constituents exert preventive effects against colorectal cancer, we evaluated the influence of oral bilirubin and sodium taurocholate (NaTC) on intestinal tumor formation in APC(Min/+) mice. Mice received bilirubin and/or bovine serum albumin (BSA) and NaTC in the...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq050
更新日期:2010-06-01 00:00:00
abstract::Observational studies suggest that fish consumption is associated with a decreased colorectal cancer (CRC) risk. A possible mechanism by which fish could reduce CRC risk is by decreasing colonic genotoxicity. However, concerns have also been raised over the levels of toxic compounds found in mainly oil-rich fish, whic...
journal_title:Carcinogenesis
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1093/carcin/bgp255
更新日期:2010-06-01 00:00:00
abstract::Transforming growth factor beta1 (TGFbeta1) expression is elevated by tumor promoters in the mouse skin, but its role in tumor promotion has not been well defined. To investigate this, we have compared TGFbeta1+/+ and +/- mice in a two-stage skin chemical carcinogenesis protocol. Surprisingly, TGFbeta1+/- mice had few...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq041
更新日期:2010-06-01 00:00:00
abstract::Although microRNAs (miRNA) have extensively been investigated in cancer research, less attention has been paid to their regulation by carcinogens and/or protective factors in early stages of the carcinogenesis process. The present study was designed to evaluate the modulation of mRNA expression as related to exposure ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq037
更新日期:2010-05-01 00:00:00